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细胞名称

人急性骨髓白血病细胞KG-1A

货物编码

BFN60810771

产物规格

T25培养瓶x1

1.5ml冻存管x2

细胞数量

1x10^6

1x10^6

保存温度

37℃

-198℃

运输方式

常温保温运输

干冰运输

安全等级

1

用途限制

仅供科研   3类

培养体系

DMEM高糖（hyclone SH3022.01）+10%FBS+1%叁抗

培养温度

37℃

二氧化碳浓度

5%

介绍

人急性骨髓白血病细胞KG-1A取自59岁男性供体

注释

Doubling time: ~45 hours (CLS); ~50 hours (DSMZ).

Omics: Transcriptome analysis.

Derived from sampling site: Bone marrow.

基因突变

FGFR1OP2-FGFR1 gene fusion (from parent cell line).

NRAS p.Gly12Asp (c.35G>A) (ClinVar=VCV000039648) (from parent cell line).

Homozygous for TP53 c.672+1G>A; splice donor mutation (from parent cell line).

HLA信息

/

STR信息

Amelogenin        X,Y

CSF1PO        7

D2S1338        20,23

D3S1358        15,16

D5S818        13

D7S820        8,10

D8S1179        13,14 (CCRID; CLS; PubMed=11416159; PubMed=25877200)

14 (COG)

D13S317        11,12

D16S539        10,11

D18S51        10.2,18

D19S433        11,16.2 (COG)

16.2 (PubMed=25877200)

D21S11        28,29

FGA        22

Penta D        8,9

Penta E        7,13

TH01        7,8

TPOX        7,9 (ATCC; CCRID; CLS; COG; DSMZ; ECACC; RCB; TKG)

7 (PubMed=25877200)

vWA        14,19

参考文献

PubMed=6967340; DOI=10.1182ood.V56.2.265.265

Koeffler H.P., Billing R., Lusis A.J., Sparkes R.S., Golde D.W.

An undifferentiated variant derived from the human acute myelogenous leukemia cell line (KG-1).

Blood 56:265-273(1980)

PubMed=3094604; DOI=10.1182ood.V68.5.1101.1101

Furley A.J.W., Reeves B.R., Mizutani S., Altass L.J., Watt S.M., Jacob M.C., van den Elsen P., Terhorst C., Greaves M.F.

Divergent molecular phenotypes of KG1 and KG1a myeloid cell lines.

Blood 68:1101-1107(1986)

PubMed=8558913

Morita S., Tsuchiya S., Fujie H., Itano M., Ohashi Y., Minegishi M., Imaizumi M., Endo M., Takano N., Konno T.

Cell surface c-kit receptors in human leukemia cell lines and pediatric leukemia: selective preservation of c-kit expression on megakaryoblastic cell lines during adaptation to in vitro culture.

Leukemia 10:102-105(1996)

DOI=10.1016/B978-0-12-221970-2.50457-5

Drexler H.G.

The leukemia-lymphoma cell line factsbook.

(In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)